Heterosubtype Neutralizing Responses to Influenza A (H5N1) Viruses Are Mediated by Antibodies to Virus Haemagglutinin
Identifieur interne : 000220 ( France/Analysis ); précédent : 000219; suivant : 000221Heterosubtype Neutralizing Responses to Influenza A (H5N1) Viruses Are Mediated by Antibodies to Virus Haemagglutinin
Auteurs : Jean-Michel Garcia [République populaire de Chine] ; Stephanie Pepin [France] ; Nadège Lagarde [République populaire de Chine] ; Edward S. K. Ma [République populaire de Chine] ; Frederick R. Vogel [France] ; Kwok H. Chan [République populaire de Chine] ; Susan S. S. Chiu [République populaire de Chine] ; J. S. M. Peiris [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2009.
Abstract
It is increasingly clear that influenza A infection induces cross-subtype neutralizing antibodies that may potentially confer protection against zoonotic infections. It is unclear whether this is mediated by antibodies to the neuraminidase (NA) or haemagglutinin (HA). We use pseudoviral particles (H5pp) coated with H5 haemagglutinin but not N1 neuraminidase to address this question. In this study, we investigate whether cross-neutralizing antibodies in persons unexposed to H5N1 is reactive to the H5 haemagglutinin.
We measured H5-neutralization antibody titers pre- and post-vaccination using the H5N1 micro-neutralization test (MN) and H5pp tests in subjects given seasonal vaccines and in selected sera from European elderly volunteers in a H5N1 vaccine trial who had detectable pre-vaccination H5N1 MN antibody titers. We found detectable (titer ≥20) H5N1 neutralizing antibodies in a minority of pre-seasonal vaccine sera and evidence of a serological response to H5N1 in others after seasonal influenza vaccination. There was excellent correlation in the antibody titers between the H5N1 MN and H5pp tests. Similar correlations were found between MN and H5pp in the pre-vaccine sera from the cohort of H5N1 vaccine trial recipients.
Heterosubtype neutralizing antibody to H5N1 in healthy volunteers unexposed to H5N1 is mediated by cross-reaction to the H5 haemagglutinin.
Url:
DOI: 10.1371/journal.pone.0007918
PubMed: 19936250
PubMed Central: 2775912
Affiliations:
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PMC:2775912Le document en format XML
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K." last="Ma">Edward S. K. Ma</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Microbiology, University of Hong Kong, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Vogel, Frederick R" sort="Vogel, Frederick R" uniqKey="Vogel F" first="Frederick R." last="Vogel">Frederick R. 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Chan</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Microbiology, University of Hong Kong, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Chiu, Susan S S" sort="Chiu, Susan S S" uniqKey="Chiu S" first="Susan S. S." last="Chiu">Susan S. S. Chiu</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>HKU-Pasteur Research Centre, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>HKU-Pasteur Research Centre, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Microbiology, University of Hong Kong, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>It is increasingly clear that influenza A infection induces cross-subtype neutralizing antibodies that may potentially confer protection against zoonotic infections. It is unclear whether this is mediated by antibodies to the neuraminidase (NA) or haemagglutinin (HA). We use pseudoviral particles (H5pp) coated with H5 haemagglutinin but not N1 neuraminidase to address this question. In this study, we investigate whether cross-neutralizing antibodies in persons unexposed to H5N1 is reactive to the H5 haemagglutinin.</p></sec><sec><title>Methodology/Principal Findings</title><p>We measured H5-neutralization antibody titers pre- and post-vaccination using the H5N1 micro-neutralization test (MN) and H5pp tests in subjects given seasonal vaccines and in selected sera from European elderly volunteers in a H5N1 vaccine trial who had detectable pre-vaccination H5N1 MN antibody titers. We found detectable (titer ≥20) H5N1 neutralizing antibodies in a minority of pre-seasonal vaccine sera and evidence of a serological response to H5N1 in others after seasonal influenza vaccination. There was excellent correlation in the antibody titers between the H5N1 MN and H5pp tests. Similar correlations were found between MN and H5pp in the pre-vaccine sera from the cohort of H5N1 vaccine trial recipients.</p></sec><sec><title>Conclusions/Significance</title><p>Heterosubtype neutralizing antibody to H5N1 in healthy volunteers unexposed to H5N1 is mediated by cross-reaction to the H5 haemagglutinin.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schulman, Jl" uniqKey="Schulman J">JL Schulman</name></author><author><name sortKey="Kilbourne, Ed" uniqKey="Kilbourne E">ED Kilbourne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yetter, Ra" uniqKey="Yetter R">RA Yetter</name></author><author><name sortKey="Barber, Wh" uniqKey="Barber W">WH Barber</name></author><author><name sortKey="Small, Pa" uniqKey="Small P">PA Small</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heinen, Pp" uniqKey="Heinen P">PP Heinen</name></author><author><name 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Hu-Primmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laddy, Dj" uniqKey="Laddy D">DJ Laddy</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author><author><name sortKey="Kutzler, M" uniqKey="Kutzler M">M Kutzler</name></author><author><name sortKey="Kobasa, D" uniqKey="Kobasa D">D Kobasa</name></author><author><name sortKey="Kobinger, Gp" uniqKey="Kobinger G">GP Kobinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khurana, S" uniqKey="Khurana S">S Khurana</name></author><author><name sortKey="Suguitan, Al" uniqKey="Suguitan A">AL Suguitan</name></author><author><name sortKey="Rivera, Y" uniqKey="Rivera Y">Y Rivera</name></author><author><name sortKey="Simmons, Cp" uniqKey="Simmons C">CP Simmons</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshida, R" uniqKey="Yoshida R">R Yoshida</name></author><author><name sortKey="Igarashi, M" uniqKey="Igarashi M">M Igarashi</name></author><author><name sortKey="Ozaki, H" uniqKey="Ozaki H">H Ozaki</name></author><author><name sortKey="Kishida, N" uniqKey="Kishida N">N Kishida</name></author><author><name sortKey="Tomabechi, D" uniqKey="Tomabechi D">D Tomabechi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Tt" uniqKey="Wang T">TT Wang</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kashyap, Ak" uniqKey="Kashyap A">AK Kashyap</name></author><author><name sortKey="Steel, J" uniqKey="Steel J">J Steel</name></author><author><name sortKey="Oner, Af" uniqKey="Oner A">AF Oner</name></author><author><name sortKey="Dillon, Ma" uniqKey="Dillon M">MA Dillon</name></author><author><name sortKey="Swale, Re" uniqKey="Swale R">RE Swale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vong, S" uniqKey="Vong S">S Vong</name></author><author><name sortKey="Coghlan, B" uniqKey="Coghlan B">B Coghlan</name></author><author><name sortKey="Sek, M" uniqKey="Sek M">M Sek</name></author><author><name sortKey="Holl, D" uniqKey="Holl D">D Holl</name></author><author><name sortKey="Seng, H" uniqKey="Seng H">H Seng</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Garcia, Jean Michel" sort="Garcia, Jean Michel" uniqKey="Garcia J" first="Jean-Michel" last="Garcia">Jean-Michel Garcia</name></noRegion><name sortKey="Chan, Kwok H" sort="Chan, Kwok H" uniqKey="Chan K" first="Kwok H." last="Chan">Kwok H. Chan</name><name sortKey="Chiu, Susan S S" sort="Chiu, Susan S S" uniqKey="Chiu S" first="Susan S. S." last="Chiu">Susan S. S. Chiu</name><name sortKey="Lagarde, Nadege" sort="Lagarde, Nadege" uniqKey="Lagarde N" first="Nadège" last="Lagarde">Nadège Lagarde</name><name sortKey="Ma, Edward S K" sort="Ma, Edward S K" uniqKey="Ma E" first="Edward S. K." last="Ma">Edward S. K. Ma</name><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name></country><country name="France"><noRegion><name sortKey="Pepin, Stephanie" sort="Pepin, Stephanie" uniqKey="Pepin S" first="Stephanie" last="Pepin">Stephanie Pepin</name></noRegion><name sortKey="Vogel, Frederick R" sort="Vogel, Frederick R" uniqKey="Vogel F" first="Frederick R." last="Vogel">Frederick R. 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